abstract：BACKGROUND:Previous research has demonstrated altered neuronal responses to visual stimulation with food in anorexia nervosa, varying with the motivational state of hunger or satiety. The aim of the present fMRI study was to assess hunger- and satiety-dependent alterations in the gustatory processing of stimulation wit...

journal_title：Journal of psychiatric research

authors： Vocks S,Herpertz S,Rosenberger C,Senf W,Gizewski ER

更新日期：2011-03-01 00:00:00

abstract：:Ghrelin showed antidepressant-like effects in mice. Furthermore, ghrelin influences sleep and the activity of hypothalamic-pituitary-adrenal (HPA) and somatotropic axis in healthy humans as indicated by increased cortisol and growth hormone (GH) plasma levels. Both sleep and the activity of these endocrine axes are di...

journal_title：Journal of psychiatric research

authors： Kluge M,Schüssler P,Dresler M,Schmidt D,Yassouridis A,Uhr M,Steiger A

更新日期：2011-03-01 00:00:00

abstract：:The objective of the current study was to delineate the optimal cutpoints for depression rating scales during pregnancy and the postpartum period and to assess the perinatal factors influencing these scores. Women participating in prospective investigations of maternal mental illness were enrolled prior to 28 weeks ge...

journal_title：Journal of psychiatric research

authors： Ji S,Long Q,Newport DJ,Na H,Knight B,Zach EB,Morris NJ,Kutner M,Stowe ZN

更新日期：2011-02-01 00:00:00

abstract：:Brief measures of anxiety-related severity and impairment that can be used across anxiety disorders and with subsyndromal anxiety are lacking. The Overall Anxiety Severity and Impairment Scale (OASIS) have shown strong psychometric properties with college students and primary care patients. This study examines sensiti...

journal_title：Journal of psychiatric research

authors： Norman SB,Campbell-Sills L,Hitchcock CA,Sullivan S,Rochlin A,Wilkins KC,Stein MB

更新日期：2011-02-01 00:00:00

abstract：:Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of previously described...

journal_title：Journal of psychiatric research

authors： Kapczinski F,Dal-Pizzol F,Teixeira AL,Magalhaes PV,Kauer-Sant'Anna M,Klamt F,Moreira JC,de Bittencourt Pasquali MA,Fries GR,Quevedo J,Gama CS,Post R

更新日期：2011-02-01 00:00:00

abstract：:Potential predictors of remission in mixed bipolar I disorder were identified using early Clinical Global Impression-Severity (CGI-S) improvement criteria in divalproex-resistant patients randomized to olanzapine augmentation (olanzapine + divalproex; N = 101) in a 6-week, double-blind, placebo-controlled trial. In a ...

journal_title：Journal of psychiatric research

authors： Houston JP,Ketter TA,Case M,Bowden C,Degenhardt EK,Jamal HH,Tohen M

更新日期：2011-02-01 00:00:00

abstract：:One important target in the treatment of major depressive disorder (MDD) is the serotonin (5-hydroxytryptamine, 5-HT) system. Selective serotonin reuptake inhibitors (SSRI) are used to treat MDD. Yet, the mode of action of these drugs is not completely understood. There is evolving evidence for a role of glutamate in ...

journal_title：Journal of psychiatric research

authors： Schipke CG,Heuser I,Peters O

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The dexamethasone-corticotropin releasing hormone (Dex-CRH) test may differentially predict which depressed patients will respond to antidepressant medication. However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed. METHODS:We conducted a poole...

journal_title：Journal of psychiatric research

authors： Dunlop BW,Betancourt Y,Binder EB,Heim C,Holsboer F,Ising M,McKenzie M,Mletzko T,Pfister H,Nemeroff CB,Craighead WE,Mayberg HS

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of rEEG(®)-guided pharmacotherapy for the treatment of depression in those circumstances where rEEG and STAR*D provided different recommendations. MATERIALS AND METHODS:This was a randomized, single-blind, parallel group, 12 center, US study of rEEG-guided pharmacotherapy vs. the mos...

journal_title：Journal of psychiatric research

authors： DeBattista C,Kinrys G,Hoffman D,Goldstein C,Zajecka J,Kocsis J,Teicher M,Potkin S,Preda A,Multani G,Brandt L,Schiller M,Iosifescu D,Fava M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:The DEX/CRH test has been proposed to be suitable as a biomarker for the prediction of treatment response in depression. METHODS:We performed the DEX/CRH test in 10 severely depressed male patients with melancholic features before initiation of antidepressant treatment with 20 mg fluoxetine. RESULTS:We fou...

journal_title：Journal of psychiatric research

authors： Paslakis G,Heuser I,Schweiger U,Deuschle M

更新日期：2010-12-01 00:00:00

abstract：:While placed on different axes of the DSM classification system, borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) have important relationships with trauma, and overlap between these disorders has long been recognized. The current study is the first to examine comorbidity of PTSD and BPD i...

journal_title：Journal of psychiatric research

authors： Pagura J,Stein MB,Bolton JM,Cox BJ,Grant B,Sareen J

更新日期：2010-12-01 00:00:00

abstract：:Schizophrenia (SCZ) is the result of DNA alterations and environmental factors, which together lead to differential protein expression and ultimately to the development of the illness. The diagnosis is based on clinical symptoms, and the molecular background of SCZ is not completely understood. The thalamus, whose dys...

journal_title：Journal of psychiatric research

authors： Martins-de-Souza D,Maccarrone G,Wobrock T,Zerr I,Gormanns P,Reckow S,Falkai P,Schmitt A,Turck CW

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Regulatory T cells (Tregs, CD4(+)CD25(hi)) are specialized in steering the immune response and cytokine release to maintain tolerance to self-antigens. As cytokines such as interleukin (IL)-1β, IL-6 and interferon (IFN)-α have been shown to be involved in the pathophysiology of depression and cytokine levels...

journal_title：Journal of psychiatric research

authors： Himmerich H,Milenović S,Fulda S,Plümäkers B,Sheldrick AJ,Michel TM,Kircher T,Rink L

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence, age of onset, severity, associated disability, and treatment of major depression among United States ethnic groups, national survey data were analyzed. METHODS:National probability samples of US household residents aged 18-years and older (n=14,710) participated. The main outcom...

journal_title：Journal of psychiatric research

authors： González HM,Tarraf W,Whitfield KE,Vega WA

更新日期：2010-11-01 00:00:00

abstract：:Individuals with body dysmorphic disorder (BDD) are preoccupied with perceived defects in appearance. Preliminary evidence suggests abnormalities in global and local visual information processing. The objective of this study was to compare global and local processing in BDD subjects and healthy controls by testing the...

journal_title：Journal of psychiatric research

authors： Feusner JD,Moller H,Altstein L,Sugar C,Bookheimer S,Yoon J,Hembacher E

更新日期：2010-11-01 00:00:00

abstract：:Poor set-shifting has been implicated as a risk marker, maintenance factor and candidate endophenotype of eating disorders (ED). This study aimed to add clarity to the cognitive profile of set-shifting by examining the trait across ED subtypes, assessing whether it is a state or trait marker, and whether it runs in fa...

journal_title：Journal of psychiatric research

authors： Roberts ME,Tchanturia K,Treasure JL

更新日期：2010-10-01 00:00:00

abstract：:Molecular knowledge about schizophrenia--a psychotic, multifactorial mental disorder that affects about 1% of the population worldwide--is limited and no diagnostic biomarkers are available. The comparative proteome analysis of human brain tissue from patients with schizophrenia and healthy controls may supply useful ...

journal_title：Journal of psychiatric research

authors： Martins-de-Souza D,Schmitt A,Röder R,Lebar M,Schneider-Axmann T,Falkai P,Turck CW

更新日期：2010-10-01 00:00:00

abstract：:Eating disorders (ED) are severe psychiatric diseases that most likely result from, and are sustained by socio-cultural, psychological and biological factors. We explored whether members of the neurotrophin family are disease-modifying factors of quantitative traits, potentially contributing to the outcome or prognosi...

journal_title：Journal of psychiatric research

authors： Gratacòs M,Escaramís G,Bustamante M,Saus E,Agüera Z,Bayés M,Cellini E,de Cid R,Fernández-Aranda F,Forcano L,González JR,Gorwood P,Hebebrand J,Hinney A,Mercader JM,Nacmias B,Ramoz N,Ribasés M,Ricca V,Romo L,Sorbi S

更新日期：2010-10-01 00:00:00

abstract：:Previous studies with 1.5 T or 3.0 T magnetic resonance imaging (MRI) have produced mixed results regarding the structural changes of the hippocampus in major depressive disorder (MDD). Subtle region-specific hippocampal tissue changes might be more sensitively detected by measuring the T2* relaxation time (T2*-RT) by...

journal_title：Journal of psychiatric research

authors： Cho ZH,Kim YB,Han JY,Kim NB,Hwang SI,Kim SJ,Cho SJ

更新日期：2010-10-01 00:00:00

abstract：:Psychological distress and coping styles have been suggested to relate to altered function in the hypothalamic-pituitary-adrenal (HPA) axis, although there remains much to be understood about their relationships. High and low cortisol levels (or reactivity) both represent HPA axis dysfunction, with accumulated evidenc...

journal_title：Journal of psychiatric research

authors： Hori H,Ozeki Y,Teraishi T,Matsuo J,Kawamoto Y,Kinoshita Y,Suto S,Terada S,Higuchi T,Kunugi H

更新日期：2010-10-01 00:00:00

abstract：:The first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive perfor...

journal_title：Journal of psychiatric research

authors： Vassos E,Bramon E,Picchioni M,Walshe M,Filbey FM,Kravariti E,McDonald C,Murray RM,Collier DA,Toulopoulou T

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to estimate suicide risk during hospitalization and in the year following discharge for patients with mental disorders. All suicide cases in Sweden 18 years and older, between 1991 and 2003 (N=20,675; 70% male), were individually matched to 10 controls from the general Swedish population. Dis...

journal_title：Journal of psychiatric research

authors： Reutfors J,Brandt L,Ekbom A,Isacsson G,Sparén P,Osby U

更新日期：2010-09-01 00:00:00

abstract：:Auditory-verbal hallucinations are a hallmark symptom of schizophrenia. In recent years, repetitive transcranial magnetic stimulation (rTMS) targeting speech perception areas has been advanced as a potential treatment of medication-resistant hallucinations. However, the underlying neural processes remain unclear. This...

journal_title：Journal of psychiatric research

authors： Vercammen A,Knegtering H,Liemburg EJ,den Boer JA,Aleman A

更新日期：2010-08-01 00:00:00

abstract：:The post-partum period is a time of extreme vulnerability for a whole spectrum of psychiatric disorders. Delivery may be considered an important risk factor in genetically susceptible women. Five hundred and eight SNPs in 44 genes at candidate pathways putatively related to mood changes after delivery were genotyped i...

journal_title：Journal of psychiatric research

authors： Costas J,Gratacòs M,Escaramís G,Martín-Santos R,de Diego Y,Baca-García E,Canellas F,Estivill X,Guillamat R,Guitart M,Gutiérrez-Zotes A,García-Esteve L,Mayoral F,Moltó MD,Phillips C,Roca M,Carracedo A,Vilella E,Sanjuán

更新日期：2010-08-01 00:00:00

abstract：:There is a body of evidence suggesting that BDNF is involved in bipolar disorder (BD) pathogenesis. Intracerebroventricular (ICV) injection of ouabain (OUA), a specific Na(+)/K(+) ATPase inhibitor, induces hyperlocomotion in rats, and has been used as an animal model of mania. The present study aims to investigate the...

journal_title：Journal of psychiatric research

authors： Jornada LK,Moretti M,Valvassori SS,Ferreira CL,Padilha PT,Arent CO,Fries GR,Kapczinski F,Quevedo J

更新日期：2010-06-01 00:00:00

abstract：:The anatomical basis of visuo-constructive impairment in AD is widely unexplored. FDG-PET can be used to determine functional neuronal networks underlying specific cognitive performance in the human brain. In the present study, we determined the pattern of cortical metabolism that was associated with visuo-constructiv...

journal_title：Journal of psychiatric research

authors： Förster S,Teipel S,Zach C,Rominger A,Cumming P,Fougere Cl,Yakushev I,Haslbeck M,Hampel H,Bartenstein P,Bürger K

更新日期：2010-05-01 00:00:00

abstract：:The methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated to high homocysteine levels and schizophrenia. Since cytokines are altered in schizophrenia and increments of homocysteine could promote an inflammatory response, it was investigated whether interleukin-6 (IL-6) and tumor necrosis facto...

journal_title：Journal of psychiatric research

authors： García-Miss Mdel R,Pérez-Mutul J,López-Canul B,Solís-Rodríguez F,Puga-Machado L,Oxté-Cabrera A,Gurubel-Maldonado J,Arankowsky-Sandoval G

更新日期：2010-05-01 00:00:00

abstract：:The current study sought to test the efficacy and safety of the novel selective norepinephrine reuptake inhibitor LY2216684 compared to placebo in patients with major depressive disorder (MDD). Escitalopram was used as a control for assay sensitivity. Adult outpatients with MDD, confirmed at screening by the Mini Inte...

journal_title：Journal of psychiatric research

authors： Dubé S,Dellva MA,Jones M,Kielbasa W,Padich R,Saha A,Rao P

更新日期：2010-04-01 00:00:00

abstract：:Psychological morbidity concurrent with fertility problems has been the focus of substantial scientific inquiry. However, researchers have largely overlooked psychological resilience within this population. This study explored the associations between resilience, infertility-related and general distress, and coping be...

journal_title：Journal of psychiatric research

authors： Sexton MB,Byrd MR,von Kluge S

更新日期：2010-03-01 00:00:00

abstract：:Bipolar disorder (BD) is characterized by frequent recurrence, incomplete recovery, cognitive dysfunction and poor functioning. Impairment lingers in the interepisodic period and mechanisms leading to this dysfunctional state are not fully comprehended. To our knowledge the association of biological rhythm dysfunction...

journal_title：Journal of psychiatric research

authors： Giglio LM,Magalhães PV,Kapczinski NS,Walz JC,Kapczinski F

更新日期：2010-03-01 00:00:00

abstract：:Speech disturbances (SD) are a pernicious symptom of schizophrenia that increase when negative emotion is elicited. This increase is referred to as affective reactivity (AR). Although considerable research has examined SD in schizophrenia, few studies have investigated this symptom in individuals at risk for the disor...

journal_title：Journal of psychiatric research

authors： Minor KS,Cohen AS

更新日期：2010-01-01 00:00:00

abstract：:Adjuvant use of nutritional and herbal medicines has potential to increase the efficacy of synthetic pharmaceuticals, and perhaps also decrease their side-effects by allowing lower doses to be prescribed. We evaluated current evidence for adjuvant use of nutritional and herbal medicines with antidepressants, mood stab...

journal_title：Journal of psychiatric research

authors： Sarris J,Kavanagh DJ,Byrne G

更新日期：2010-01-01 00:00:00

abstract：:Although serotonin (5-HT) genes are thought to be involved in the etiology of bulimia nervosa and binge eating, findings from molecular genetic studies are inconclusive. This may be due to limitations of past research, such as a failure to consider the influence of quantitative traits and gene-environment interactions...

journal_title：Journal of psychiatric research

authors： Racine SE,Culbert KM,Larson CL,Klump KL

更新日期：2009-12-01 00:00:00

abstract：:Blood-injury-injection (BII) phobia presents with a unique anxiety response that often involves blood pressure drops and pronounced bradycardia, which can culminate in fainting. The current recommended treatment for BII phobia is Applied Tension (AT), a tension technique that includes in vivo exposure. However, surpri...

journal_title：Journal of psychiatric research

authors： Ayala ES,Meuret AE,Ritz T

更新日期：2009-10-01 00:00:00

abstract：:Structural neuroimaging studies investigating amygdala volumes in patients suffering from major depression have yielded variable results. Discrepant findings across studies may be attributable in part to heterogeneity with respect to antidepressant medication and to lack of adequate control for the effects of total br...

journal_title：Journal of psychiatric research

authors： Kronenberg G,Tebartz van Elst L,Regen F,Deuschle M,Heuser I,Colla M

更新日期：2009-09-01 00:00:00

abstract：:Regular physical activity is anxiolytic in both healthy subjects and patients with panic disorder. In contrast, acute exercise may induce acute panic attacks or increase subjective anxiety in patients with panic disorder more than in other people. The effects of quiet rest or an aerobic treadmill exercise (30 min at a...

journal_title：Journal of psychiatric research

authors： Ströhle A,Graetz B,Scheel M,Wittmann A,Feller C,Heinz A,Dimeo F

更新日期：2009-08-01 00:00:00

abstract：:Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted inte...

journal_title：Journal of psychiatric research

authors： McCloskey MS,New AS,Siever LJ,Goodman M,Koenigsberg HW,Flory JD,Coccaro EF

更新日期：2009-08-01 00:00:00

abstract：:Acute alcohol use is an important risk factor for attempted and completed suicide. We evaluated the effect of acute alcohol intake on the lethality of suicide attempts to test the hypothesis that acute alcohol intoxication is associated with more lethal suicide attempts. This retrospective study included 317 suicide a...

journal_title：Journal of psychiatric research

authors： Sher L,Oquendo MA,Richardson-Vejlgaard R,Makhija NM,Posner K,Mann JJ,Stanley BH

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Anxiety disorders and insomnia are each prevalent, impairing, and highly comorbid. However, little is known about whether specific types of sleep complaints are associated with specific anxiety disorders, and whether poor sleep has an additive effect on functional impairment in anxiety disorders. METHOD:Dat...

journal_title：Journal of psychiatric research

authors： Ramsawh HJ,Stein MB,Belik SL,Jacobi F,Sareen J

更新日期：2009-07-01 00:00:00

abstract：:Narcissistic personality disorder is the subject of extensive discussion in the literature. Yet, the validity of this diagnostic category remains questionable. This is owed, in large part, to the relative absence of empirical work that has examined narcissism in clinical samples. Descriptions and findings from studies...

journal_title：Journal of psychiatric research

authors： Ogrodniczuk JS,Piper WE,Joyce AS,Steinberg PI,Duggal S

更新日期：2009-06-01 00:00:00